In 2024, 2.8% of Americans age 12 and older used psilocybin in the past year, equal to about 8 million people. Use was higher among adults 18–25, men, college-educated adults, cannabis users, and people who had used LSD, ketamine, or MDMA in the same year. People with a past-year major depressive episode also had higher odds of psilocybin use, making this a key public-health snapshot as psychedelics move further into everyday life.