Fungi produce structurally diverse anticancer molecules, with ~1.5 million species estimated and only a small fraction studied, representing a large untapped drug source . Specific compounds show strong activity, including acetoxyscirpenediol with IC50 values of 1.2–4.0 μM across tumor cell lines and leucinostatin A inhibiting breast cancer cells at just 2.3 nM . These compounds work by blocking cell division, triggering apoptosis, and disrupting cancer cell signaling.