Mood & Mental Health

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Study

One Psilocybin Dose Brought Fast Depression Remission

One Psilocybin Dose Brought Fast Depression Remission

Psilocybin mushrooms

What they found

After a single 25 mg psilocybin session, 52.9% of adults with major depression were in remission by 6 weeks versus 5.9% on placebo.

After a single 25 mg psilocybin session, 52.9% of adults with major depression were in remission by 6 weeks versus 5.9% on placebo.

The number

(52.9%) reached remission by 6 weeks versus just 5.9% in the placebo group

How solid is it?

Early human

Early human

Human – RCT

Human – RCT

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

watermark02.silverchair.com

watermark02.silverchair.com

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

One Dose Impact

One Dose Impact

Adults with major depression experienced symptom improvements within 48 hours after a single 25 mg psilocybin session, with benefits lasting beyond 100 days on self-reported measures. More than half of participants (52.9%) reached remission by 6 weeks versus just 5.9% in the placebo group, highlighting one of the fastest antidepressant responses seen in psychiatric research.

Adults with major depression experienced symptom improvements within 48 hours after a single 25 mg psilocybin session, with benefits lasting beyond 100 days on self-reported measures. More than half of participants (52.9%) reached remission by 6 weeks versus just 5.9% in the placebo group, highlighting one of the fastest antidepressant responses seen in psychiatric research.

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