Brain & Cognition

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Review

Psilocybin May Lower Inflammation Linked to Brain Aging

Psilocybin May Lower Inflammation Linked to Brain Aging

Psilocybin mushrooms

What they found

A preprint review reports single psilocybin doses lowered IL-6 and CRP for up to 7 days.

A preprint review reports single psilocybin doses lowered IL-6 and CRP for up to 7 days.

The number

for up to 7 days after a single dose

How solid is it?

Review

Review

Narrative review

Narrative review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Preprints.org

Preprints.org

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Brain Aging Support

Brain Aging Support

Psilocybin (20–30 mg doses in clinical settings or ~0.2–0.3 mg/kg) reduced inflammatory markers and lowered IL-6 and CRP levels for up to 7 days after a single dose. It activates 5-HT2A receptors, restoring neural flexibility in aging brain regions. This combination improves mood, cognition, and resilience while targeting the underlying inflammation linked to depression and neurodegeneration.

Psilocybin (20–30 mg doses in clinical settings or ~0.2–0.3 mg/kg) reduced inflammatory markers and lowered IL-6 and CRP levels for up to 7 days after a single dose. It activates 5-HT2A receptors, restoring neural flexibility in aging brain regions. This combination improves mood, cognition, and resilience while targeting the underlying inflammation linked to depression and neurodegeneration.

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