Mood & Mental Health

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Study

Psilocybin Reversed Chronic Stress Damage in Rats

Psilocybin Reversed Chronic Stress Damage in Rats

Psilocybin mushrooms

What they found

Two psilocybin doses a week apart reversed stress-induced depressive behavior and restored brain connectivity in rats.

Two psilocybin doses a week apart reversed stress-induced depressive behavior and restored brain connectivity in rats.

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Stress Damage Reversal

Stress Damage Reversal

Psilocybin (0.6 mg/kg, given twice 7 days apart) reversed anhedonia and depressive-like behavior caused by chronic stress in rats while restoring disrupted brain connectivity. It rebuilt neuroplasticity in key mood-regulating regions, reversing stress-driven loss of synaptic function and behavioral deficits. This directly repairs stress-related brain damage, improving resilience, mood, and cognitive function after prolonged stress exposure.

Psilocybin (0.6 mg/kg, given twice 7 days apart) reversed anhedonia and depressive-like behavior caused by chronic stress in rats while restoring disrupted brain connectivity. It rebuilt neuroplasticity in key mood-regulating regions, reversing stress-driven loss of synaptic function and behavioral deficits. This directly repairs stress-related brain damage, improving resilience, mood, and cognitive function after prolonged stress exposure.

Shroom Scan #113: Psilocybin repairs stress damage, reishi blocks cancer spread, and fungi kill ticks

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