Addiction

·

Study

Psilocybin Therapy Cut Cocaine Relapse Risk by 72%

Psilocybin Therapy Cut Cocaine Relapse Risk by 72%

Psilocybin mushrooms

What they found

In 40 adults with cocaine use disorder, psilocybin plus therapy cut relapse risk by 72% and increased abstinent days by 29% versus placebo.

In 40 adults with cocaine use disorder, psilocybin plus therapy cut relapse risk by 72% and increased abstinent days by 29% versus placebo.

The number

cut relapse risk by 72%

How solid is it?

Early human

Early human

Human – RCT

Human – RCT

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

40 adults

40 adults

Published in

JAMA Network

JAMA Network

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Addiction Treatment Expansion

Addiction Treatment Expansion

Psilocybin at 25 mg/70 kg plus manualized psychotherapy increased cocaine-abstinent days by 29% versus active placebo through 180 days. In 40 adults with cocaine use disorder, psilocybin also raised the likelihood of complete abstinence 18.37× and cut relapse risk by 72%, with no serious adverse events. This is a major psychedelic milestone because cocaine use disorder has no proven medication, and the trial reached underserved participants, including 82.5% Black adults and 65% earning $20,000 or less per year.

Psilocybin at 25 mg/70 kg plus manualized psychotherapy increased cocaine-abstinent days by 29% versus active placebo through 180 days. In 40 adults with cocaine use disorder, psilocybin also raised the likelihood of complete abstinence 18.37× and cut relapse risk by 72%, with no serious adverse events. This is a major psychedelic milestone because cocaine use disorder has no proven medication, and the trial reached underserved participants, including 82.5% Black adults and 65% earning $20,000 or less per year.

Shroom Scan #116: Psilocybin cuts cocaine relapse 72%, 24M Americans microdosing, and lion's mane coffee

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