Mood & Mental Health

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Review

Psilocybin Trials Promising but Not Very Diverse

Psilocybin Trials Promising but Not Very Diverse

Psilocybin mushrooms

What they found

A review found up to 71% response rates in depression trials, but samples are small and often about 90% white.

A review found up to 71% response rates in depression trials, but samples are small and often about 90% white.

The number

up to 71% response rates and 54% remission at 4 weeks

How solid is it?

Review

Review

Narrative review

Narrative review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Brain Sciences

Brain Sciences

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Beyond Clinical Trials

Beyond Clinical Trials

Psilocybin shows strong effects across depression, anxiety, and addiction, with up to 71% response rates and 54% remission at 4 weeks in major depression trials. However, most studies rely on small, highly selective samples (often ~90% white participants) and struggle with placebo control, limiting real-world accuracy.

Psilocybin shows strong effects across depression, anxiety, and addiction, with up to 71% response rates and 54% remission at 4 weeks in major depression trials. However, most studies rely on small, highly selective samples (often ~90% white participants) and struggle with placebo control, limiting real-world accuracy.

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