Fungi isolated from high-radiation soil survived extreme doses up to 8 kGy and maintained growth under uranium and thorium exposure up to 1000 ppm. Within 24 hours, isolates like Talaromyces flavus and Gongronella butleri absorbed up to 97% of uranium and 100% of thorium, with measurable biomass gains up to 4.11 g. These fungi use biosorption, melanin binding, and enzymatic processes to capture and neutralize radioactive metals, enabling direct cleanup of contaminated environments.